Resident Evil 4 počela kao gamecube ekskluziva. Mikami izjavljuje:
"I will cut my head off if Resident Evil 4 comes to the PlayStation 2...".
Resident Evil 4 was ported to the following platforms:
PlayStation 2, Microsoft Windows, Wii, Zeebo, iOS, PlayStation 3, Xbox 360, Android, PlayStation 4, Xbox One and of course Gamecube as the OG platform.
